[摘要]：An asym. total synthesis of (+)-cis-sylvaticin [I, X = (CH2)7, Y = (CH2)9] is described. Key steps include the use of permanganate-mediated oxidative cyclization of 1,5-dienes to synthesize the two major fragments II and III and a catalytically efficient tethered RCM to unite these THF-contg. fragments. In addn., tert-BuP4 base was found to reliably promote rapid alkylation of the butenolide precursor fragment IV.
