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[摘要]:Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl譒iCl furnish, after trapping with various electrophiles, highly functionalized derivs., e.g. I, in good to excellent yields. Applications to the synthesis of antiviral and anti-inflammatory agents such as p38 and sPLA2 kinase inhibitors are reported. |
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