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Electrophile-Induced Dearomatizing Spirocyclization of N-Arylisonicotinamides: A Route to Spirocyclic Piperidines.

  作者 Arnott, Gareth;Brice, Heloise;Clayden, Jonathan;Blaney, Emma;  
  选自 期刊  Organic Letters;  卷期  2008年10-14;  页码  3089-3092  
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[摘要]Treatment of N-arylisonicotinamides with trifluoromethanesulfonic anhydride triggers intramol. nucleophilic attack of the aryl ring on the 4-position of the pyridinium intermediate. The products are spirocyclic dihydropyridines, e.g. I, which can be converted to valuable spirocyclic piperidines related to biol. active mols.

 
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