[摘要]:An enantioselective synthesis of (-)-kendomycin (I) is described and is based on the application of the organosilane-based [4 + 2]-annulation strategy for the assembly of the C1a-C10 fragment. An underutilized samarium(II) iodide-assisted cyclization (intramol. Barbier-type reaction) is employed to afford the protected macrocycle. |