Exploration of the molecular origin of the azinomycin epoxide: Timing of the biosynthesis revealed.

[摘要]：Streptomyces sahachiroi whole cell feeding expts., utilizing putative precursors labeled with stable isotopes, established that the epoxide unit of the DNA crosslinked agents, azinomycin A and B, proceeds via a valine-dependent pathway and that hydroxylation and dehydration precedes formation of the terminal epoxide. Sodium 3-methyl-2-oxobutenoate, formed through a transamination reaction, was shown to be the penultimate precursor incorporated into the azinomycin epoxide.

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