| |
[摘要]：has been enormous, and their study continues to influence research in the fields of chem., biol., and ecol. Historically, the majority of our medicines originate from natural products and their synthetic derivs., many of which have taught us valuable lessons about biol. While advances in synthetic and combinatorial chem. have given rise to notable successes in the development of new drugs, the perceived value of natural products has not waned when it comes to treating infectious diseases. In this Miniperspective, we review the role natural products have played in the treatment of tuberculosis (TB), their value and limitations as chem. probes, the challenges assocd. with TB drug development, and the current status of natural product and synthetic small mols. as new TB drug leads. |
|
