[摘要]：and derivs. in C57BL/KsJ db/db diabetic mice, following identification by random screening of R2NHC(:NH)NHR1.MeSO3H (R1 = prenyl, R2 = 6-aminohexyl; R1 = prenyl, R2 = 4-aminobutyl) as potential antihyperglycemics and/or modulators of food intake. These compds. are related to galegine, a g,g-dimethylallylguanidine. Between the newly identified compds., N-(cyclopropylmethyl)-N'-(4-(aminomethyl)cyclohexylmethyl)guanidine showed the most balanced activity as an antihyperglycemic and food intake-reducing agent.
