Ni(II), Cu(II), and Zn(II) Diethyldithiocarbamate Complexes Show Various Activities Against the Proteasome in Breast Cancer Cells.

[摘要]：Three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) were prepd., confirmed by x-ray crystallog., and tested in human breast cancer MDA-MB-231 cells. Zn and Cu complexes, but not Ni complex, are more active against cellular 26S proteasome than against purified 20S proteasome core particle. One of the possible explanations is inhibition of JAMM domain in the 19S proteasome lid.

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