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A facile synthesis of 1,3-dihydroisobenzofurans using iodocyclization of 2-vinylbenzyl alcohols.

  作者 Kobayashi, Kazuhiro;Shikata, Kazuaki;Fukamachi, Shuhei;Konishi, Hisatoshi;  
  选自 期刊  Heterocycles;  卷期  2008年75-3;  页码  599-609  
  关联知识点  
 

[摘要]An efficient route for the prepn. of 1,3-dihydroisobenzofurans based on the iodine-mediated cyclization of 2-vinylbenzyl alcs., which can be prepd. feasibly by reactions of 2-vinylphenyllithiums with carbonyl compds., is reported. Substitution reactions of the iodo moiety of the resulting 1-(iodomethyl)-1,3-dihydroisobenzofurans with tributyltin hydride and sodium thiolates are also described.

 
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