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[摘要]:Syntheses of various 6-dialkylaminoalkyldiquino-1,4-thiazines and 6-aminoalkyldiquino-1,4-thiazines were elaborated in the reactions of diquino-1,4-dithiin and 2,2'-dichloro-3,3'-diquinolinyl sulfide with primary amines, and 6H-diquino-1,4-thiazine with dialkylaminoalkyl chlorides and phthalimidoalkyl bromides followed by hydrolysis. 6-Aminoalkyldiquino-thiazines were transformed into acyl and sulfonyl derivs. Some of the obtained compds. showed significant anticancer activity. |
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