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Synthesis of 6-aminoalkyldiquino-1,4-thiazines and their acyl and sulfonyl derivatives.

  作者 Jelen, Malgorzata;Pluta, Krystian;  
  选自 期刊  Heterocycles;  卷期  2008年75-4;  页码  859-870  
  关联知识点  
 

[摘要]Syntheses of various 6-dialkylaminoalkyldiquino-1,4-thiazines and 6-aminoalkyldiquino-1,4-thiazines were elaborated in the reactions of diquino-1,4-dithiin and 2,2'-dichloro-3,3'-diquinolinyl sulfide with primary amines, and 6H-diquino-1,4-thiazine with dialkylaminoalkyl chlorides and phthalimidoalkyl bromides followed by hydrolysis. 6-Aminoalkyldiquino-thiazines were transformed into acyl and sulfonyl derivs. Some of the obtained compds. showed significant anticancer activity.

 
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