Synthesis of 2,4-disubstituted isoquinolin-1(2H)-ones based on reactions of a-substituted 2-lithio-b-methoxystyrenes with isocyanates.

[摘要]：An efficient method for the prepn. of 2,4-disubstituted isoquinolin-1(2H)-ones is described. The reaction of a-substituted 2-lithio-b-methoxystyrenes, generated by treating a-substituted 2-bromo-b-methoxystyrenes with butyllithium, with isocyanates yields the corresponding a-substituted 2-(2-methoxyvinyl)benzamide derivs., which in turn are transformed into 2,4-disubstituted isoquinolin-1(2H)-ones on treatment with a catalytic amt. of concd. hydriodic acid.

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