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[摘要]：This review reports how the author has been realizing his synthetic philosophy and five dreams as his life work. The philosophy consists of such three elements as originality rate, intellectual property factor, and application potential factor. On the basis of these elements, an ideal and an efficient synthesis are defined. In the study for the total synthesis of ergot alkaloids, the first concrete example of an approx. ideal synthesis was demonstrated. Further examples are shown relying on the chem. of 1-hydroxyindoles. A lot of intellectual properties created by the author are successfully condensed to provide promising lead compds. meeting for the resp. dreams of developing five drugs for making desert green and food increase in prodn., for cardiovascular system disease, for dementia, for lifestyle-related disease (osteoporosis, etc.), and for cancer and virus. With potent promoters of plant root growth in hand, the first dream is going now successfully. Preliminary expts. combating desertification at Gobi desert in Inner Mongolia are reported in detail, aiming for preventing global warming. |
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