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Conformationally constrained adamantaneoxazolines of pharmacological interest.

  作者 Papanastasiou, Ioannis;Foscolos, George B.;Tsotinis, Andrew;Olah, Judit;Ovadi, Judit;Prathalingam, S. Radhika;Kelly, John M.;  
  选自 期刊  Heterocycles;  卷期  2008年75-8, 7/30/08;  页码  2043-2061  
  关联知识点  
 

[摘要]New conformationally constrained adamantane 2-oxazoline building blocks were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compds. affect tubulin polymn., this does not make a major contribution to trypanocidal activity.

 
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