Synthesis of new thiazolo[3,2-a]pyrimidin-5-one derivatives in reaction of 3-allyl-2-thiouracil cyclization.

[摘要]：The series of thiazolo[3,2-a]pyrimidin-5-one derivs. through cyclization reaction of 3-allyl-2-thiouracil derivs. with iodine monochloride, followed by hydrogen iodide elimination has been obtained. On the basis of the studies of reaction kinetics, the elimination reaction mechanism has been proposed. Moreover, the influence of substituent on the reaction elimination rate has been investigated.

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