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[摘要]：This review presents the current state-of-the-art synthesis for the formation of enantiomerically enriched all-carbon quaternary stereocenters in acyclic system relies on the formation of a single carbon-carbon bond per chem. step by asym. catalysis. These extraordinary sophisticated methods were logically classified among the most powerful and innovative ones. In this review article, we are proposing a new retrosynthetic paradigm to solve differently such challenging problems. These new synthetic pathways lead to the diastereo- and enantiomerically pure formation of three new carbon-carbon bonds in acyclic system, in a one-pot reaction, including the formation of all-carbon quaternary stereocenters by using classical reagents and exptl. conditions and from common starting materials. |
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