Highly chemo- and enantioselective hydrogenation of linear a,b-unsaturated ketones.

[摘要]：Highly chemo- and enantioselective hydrogenations of linear b,b-disubstituted enones have been accomplished using iridium complexes bearing chiral sulfoximine-type P,N-ligands. The catalyst system preferentially hydrogenates the C=C double bonds giving satd. ketones as the major products. Substrates with bulky substituents at the b-position give the best enantioselectivities. Thus, enones with iso-Pr and cyclohexyl substituents afford ketones with 97% ee (at >95% conversion).

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