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Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.

  作者 Paterson, Ian;Naylor, Guy J.;Wright, Amy E.;  
  选自 期刊  Chemical Communications;  卷期  2008年-38;  页码  4628-4630  
  关联知识点  
 

[摘要]A potent dictyostatin-discodermolide hybrid I was designed and synthesized; it showed enhanced cell growth inhibitory activity relative to discodermolide in four human cancer cell lines including the Taxol-resistant NCI/ADR-Res cell line.

 
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