New organotin(IV) complexes with heterocyclic thioamides 2-mercapto-benzothiazole (Hmbzt), 5-chloro-2-mercapto-benzottliazole (Hcmbzt) and 2-mercapto-benzoxazole (Hmbzo) of formulae [(C6H5)(3)Sn(mbzt)] (1), [(C6H5)(3)Sn(cmbzt)] (3) and [(C6H5)(2)Sn(cmbzt)(2)] (4), together with the already known [(C6H5)(3)Sn(mbzo)] (2), [(n-C4H9)(2)Sn(cmbZt)(2)] (5) and [(CH3)(2)Sn(cmbzt)(2)] (6) were used to study their influence on the peroxidation of oleic acid. The influence of complexes (3)-(6) upon peroxidation of oleic acid showed that the formation of reactive radicals caused the initiation of the chain radical oxidation of the substrate. The influence of complexes (1)-(6) upon the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX) was also studied and compared to those of cisplatin. Compounds (1)-(6) were finally tested for in vitro cytotoxicity against leiomyosarcoma cells. (c) 2007 Elsevier Masson SAS. All rights reserved.
