Bioorganic & Medicinal Chemistry Letters ——个性化文献订阅—

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A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties

作者	Choong, IC; Serafimova, I; Fan, JF; Stockett, D; Chan, E; Cheeti, S; Lu, YF; Fahr, B; Pham, P; Arkin, MR; Walker, DH; Hoch, U

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2008年18-21; 页码 5763-5765

关联知识点

[摘要]：The identification of a selective CDK2, 7, 9 inhibitor 4 with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice. (C) 2008 Elsevier Ltd. All rights reserved.
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