[摘要]:A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modi. cation of the hinge-binding amine or the C(2)- and C(6)- substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3 beta. (C) 2008 Elsevier Ltd. All rights reserved.