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A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two independent, sensitive spectroscopic methods

  作者 Hernandez-Folgado, L; Schmuck, C; Tomic, S; Piantanida, I  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2008年18-9;  页码  2977-2981  
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[摘要]At micromolar concentrations and equimolar conditions in respect to basepairs, a novel pyrene-guanidiniocarbonyl-pyrrole cation 1 exhibited a strong ICD signal at about lambda = 300 nm specifically upon the interaction with ds-DNA, while under the same conditions a new fluorescence maximum at lambda = 480 nm appeared exclusively upon the addition of ds-RNA. (C) 2008 Elsevier Ltd. All rights reserved.

 
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