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[摘要]：The purpose of this study was to clarify the manner in which dietary iron deficiency decreased bone mineral density (BMD) in rats. Eighteen 3-wk-old male Wistar rats were divided into 3 groups of 6 rats each. The rats in 2 of the 3 groups had free access to a control diet (C group) or an iron-deficient diet (ID group) for 4 wk. The rats in the third group (PF group) were pairfed the control diet to the mean intake of the I D group. Compared with the C and PF groups, hematocrit and hemoglobin concentrations were significantly reduced and bone mine raI content and BMD of the femur were significantly lower in the I D group. Bone histomorphometric parameters showed that the bone formation rate and osteoclast surface in the lumbar vertebra were significantly reduced in the ID group compared with the C and PF groups. Furthermore, dietary iron deficiency decreased serum 1,25-dihydroxycholecalciferol, insulin-like growth factord, and osteocalcin concentrations and urinary excretion of deoxypyriclinoline. These results suggest that severe iron deficiency decreases not only bone formation but also bone resorption. J. Nutr. 139: 238-243, 2009. |
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