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Antineoplastic agents. 558. Ampelocissus sp cancer cell growth inhibitory constituents

  作者 Pettit, GR; Mukku, VJRV; Cragg, G; Herald, DL; Knight, JC; Herald, CL; Chapuis, JC  
  选自 期刊  Journal of natural products;  卷期  2008年71-1;  页码  130-133  
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[摘要]An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.

 
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