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Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida

  作者 Ge, X; Ye, G; Li, P; Tang, WJ; Gao, JL; Zhao, WM  
  选自 期刊  Journal of natural products;  卷期  2008年71-2;  页码  227-231  
  关联知识点  
 

[摘要]Three new ent-kaurane diterpenoids, named pterokaurane M-1-M-3 (1-3) and three new C-14 pterosin-sesquiterpenoids, named multifidoside A-C (4-6), along with 18 known compounds, were isolated from the whole plants of Pteris multifida. The structures of 1-6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC50 values of less than 10 mu M.

 
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