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[摘要]：Two new labdane diterpenes, 8 alpha,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8 alpha,12,14-triol (2), as well as an acetylated derivative, 8 alpha-0-beta-D-glucopyranosyllabd-13E-ene-15,19-diol-8 alpha-2',3',4',6'-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, la and 2a, against cyclooxygenases (COX-1 and COX-2) was detected. |
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