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Cyclopeptides with anti-inflammatory activity from seeds of Annona montana

  作者 Chuang, PH; Hsieh, PW; Yang, YL; Hua, KF; Chang, FR; Shiea, J; Wu, SH; Wu, YC  
  选自 期刊  Journal of natural products;  卷期  2008年71-8;  页码  1365-1370  
  关联知识点  
 

[摘要]Four new cyclopeptides, cyclomontanins A-D (1-4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of I was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.

 
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