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[摘要]：Chemical investigation of the hexane extract of the sponge Diacarnus megaspinorhabdosa provided a series of new norterpene derivatives including three norditerpene cyclic peroxides, diacarperoxides A, B, and C (1 to 3), four norsesterterpene cyclic peroxides, diacarperoxides D to G (4 to 7), and the acyclic norsesterterpene diacardiol A (8). In addition, known norterpene peroxide congeners were also isolated, which included a known norsesterterpene cyclic peroxide (9), nuapapuin A methyl ester (10), epimuqubilin B (11), methyl-2-epinuapapuinoate (12), and methyl diacarnoate A (13). The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic studies (H-1, C-13, COSY, HMQC, HMBC. and ROESY) as well as by mass spectrometric analyses. The relative configuration of chiral centers at C-2. C-3, and C-6 was assigned by established empirical rules. All compounds were evaluated for their cytotoxic properties ill vitro using several human as well as murine cancer cell lines. |
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