Bradykinin B-1 Receptor Antagonists as Novel Analgesics: A Retrospective of Selected Medicinal Chemistry Developments

[摘要]：

Bradykinin B-1 receptor antagonists embody a potentially novel approach for the treatment of chronic pain and inflammation. The identification of non-peptide B-1 antagonists has been a notable advance in the kinin field that will allow evaluation of their therapeutic potential in the clinical realm. The current review is a high level summary of our contributions to the area that culminated in the discovery of a clinical candidate.

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