Modulation of the Rate of Peptidyl Transfer on the Ribosome by the Nature of Substrates

[摘要]：The ribosome catalyzes peptide bond formation between peptidyl-tRNA in the P site and aminoacyl-tRNA in the A site. Here, we show that the nature of the C-terminal amino acid residue in the P-site peptidyl-tRNA strongly affects the rate of peptidyl transf

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