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Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates

  作者 Lin, G; Tsu, C; Dick, L; Zhou, XK; Nathan, C  
  选自 期刊  Journal of Biological Chemistry;  卷期  2008年283-49;  页码  34423-34431  
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[摘要]The proteasome of Mycobacterium tuberculosis (Mtb) is a validated and drug-treatable target for therapeutics. To lay groundwork for developing peptide-based inhibitors with a useful degree of selectivity for the Mtb proteasome over those of the host, we u

 
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