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[摘要]：Background: Betahistine is an orally administered, centrally acting histamine H, receptor agonist with partial H-3 antagonistic activity and no H-2-bincling effects. In the past betahistine was clinically studied mainly as a vasodilator for conditions such as cluster headaches, vascular dementia and Meniere's disease, for which it is still used. in recent years, histamine was found to be a key neurotransmitter in the regulation of feeding behavior. Objective: To provide a review of the developmental history and current research interests of betahistine. Methods: All reports of betahistine use in animals and humans were retrieved and reviewed. Results/conclusion: The unique pharmacologic properties of betahistine point to its potential future use as an antiobesity agent. |
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