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Lumutinines A-D, Linearly Fused Macroline-Macroline and Macroline-Sarpagine Bisindoles from Alstonia macrophylla

  作者 Lim, SH; Tan, SJ; Low, YY; Kam, TS  
  选自 期刊  Journal of natural products;  卷期  2011年74-12;  页码  2556-2562  
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[摘要]Four new linearly fused bisindole alkaloids, lumutinines A D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline-macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision.

 
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