Microwave-irradiated transition-metal catalysis: rapid and efficient dehydrative carbon-carbon coupling of alcohols with active methylenes.

[摘要]：A rapid and highly productive synthetic microwave-irradn. protocol for transition-metal-catalyzed C-C coupling of a wide range of benzylic/allylic alcs. with b-diones, b-keto esters, and malonates is reported. In a representative screening of transition-metal catalysts, Zn, Cu, Fe, Sc, Ru, Pt, Ta, and Mo salts furnished the coupling products. Among these catalysts, Cu(II) triflate was found superior to other catalysts even in the case of a less reactive benzyl alc. or diester. Interestingly, these microwave-irradiated reactions are performed in a more or less microwave-transparent medium, such as toluene, having a very low tand, or under neat conditions.

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