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[摘要]：Three new homoisoflavanones, 1-3, together with a known one, 4, were obtained from the AcOEt extract of the tuberous root of Ophiopogon japonicus (Liliaceae). They were identified as (3R)-2,3-(1,3-benzodioxol-5-methoxy-3-(4-methoxybenzyl)-6,8-dimethyl-4H-chromen-4-one (1), (3R)-3-(1,3-benzoldioxol-5-ylmethyl)-2,3-dihydro-7-hydroxy-5-methoxy-6-methyl-4H-chromen-4-one (2), (3R)-3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-7-hydroxy-6-methyl-4H-chromen-4-one (3), and ophiopogonanone A(4). Their structures were determined on the basis of extensive NMR-spectroscopic and mass-spcetrometric analyses. The three enw compounds are rare homoisoflavanones which contian a MeO group at C(5). Compounds 1 and 2 showed weak cyotoxicity against the HepG2 (human hepatoma G2), KB (human oral epidermoid carcinoma), and MCF-7 (human breast adenocarcinoma) cell lines in an MTT assay. Compound 3 exhibited weak cytotoxicity against HepG2 and MCF-7 and moderate cytotoxicity against KB cell lines. Compound 4 showed moderated cytotoxicity against HepG2, KB, and MCF-7 cell lines. |
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