Synthesis of Novel Polycyclic Indole-Annulated Thiopyranocoumarin Derivatives via Domino Knoevenagel-Hetero-Diels-Alder Reaction in Aqueous Media

[摘要]：A efficient synthesis of polycyclic indole derivatives is achieved via domino Knoevenagel-hetero-Diels-Alder reaction of O-acrylated salicylaldehyde derivatives with dihydroindole-2-thiones in H2O as solvent. The products are formed in good-to-excellent yields with high regio- and stereoselectivity.

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