Synthetic Tripodal Squaramido-Based Receptors for the Complexation of Antineoplastic Folates in Water

[摘要]：Three suitably oriented squaramido ammonium groups form the basis of the first abiotic receptor that employs the noncovalent ammonium-carboxylate electrostatic interaction and a hydrogen bond to achieve high-affinity molecular recognition in water. These interacctions have been studied experimentally by isothermal calorimetry (ITC), NMR spectroscopy, and MS. Also, we have proposed a model for coordination from DFT calculations and NMR spectroscopy studies. Finally, a fluorimetric ensemble of the receptor with 5-carboxyfluorescein was useful for the quantitative fluorimetric determination of folate and methotrexate in commercial samples using competition assays.

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