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[摘要]：The potential of peptides as drug candidates is limited by their poor pharmacokinetic properties. Many peptides have a short half-life, in vivo half-life, and insufficient oral availability. Inspired by the N-methylation of peptides as a promising way to rationally improve key pharmacokinetic characteristics, we report our efforts toward an easy synthesis of new monomers N-beta-Fmoc-N-beta-Me-aza-beta(3)-amino acids. These synthetic building blocks will be useful for solid-phase synthesis of new peptidomimetics. |
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