An Efficient Procedure for the Synthesis of alpha,beta-Unsaturated Ketones and Its Application to Heterocyclic Systems

[摘要]：An efficient and room-temperature procedure is developed for high yield synthesis of novel alpha,beta-unsaturated derivatives of thiopyran 3 directly from ketone 1 and various aldehydes in the presence of catalytic quantities of TMSNMe(2) and MgBr(2)center dot OEt(2) under solvent-free conditions. The main advantage of the procedure is that the formation of the undesired bis by-products is minimized. In addition, the procedure is applicable to other enolizable carbocyclic and acyclic ketones.

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