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[摘要]：The key transcription regulator hypoxia-inducible factor (HIF) is commonly overexpressed in a variety of human malignancies, including multiple myeloma. It regulates the transcription of a broad range of genes involved not only in tumor angiogenesis, but also in other aspects of cancer biology. Most of our knowledge of HIF derives from studies investigating a role for HIF under hypoxic conditions; however, HIF-1 alpha stabilization is also found under normoxic conditions. HIF therefore evolved as a promising target for cancer therapies during the last decade. Ongoing efforts aim to identify derived HIF inhibitors and test their preclinical and clinical activity. |
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