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[摘要]：A series of g-cyclodextrins (CDs) modified with capping and non-capping arom. group(s) were synthesized to mediate the enantiodifferentiating [4 + 4] photocyclodimerization of 2-anthracenecarboxylic acid (AC). The complexation behavior of these g-CDs with AC was studied by CD, UV-vis, and NMR spectroscopy to reveal the formation of stable 1:2 host-guest complexes in all cases. The capped g-CD with a biphenyl group bridging the A and D glucose units was shown to confine the included AC mols. most strictly among the capped and non-capped g-CDs examd. Photocyclodimerization of AC mediated by capped g-CDs considerably improved the yield and enantiomeric excess (ee) of the head-to-head photodimer 3. The ee and the abs. configuration of syn-head-to-tail photodimer 2 critically depended on the rigidity of capping. Thus, the flexibly capped and rim-substituted g-CDs afforded 2 in moderate ee's of around 40%, whereas g-CD with a rigid biphenyl cap gave the antipodal 2 in -58% ee. Interestingly, the ee of 2 mediated by flexibly capped g-CDs was highly sensitive to the temp. variation as a consequence of large differential entropy changes in the enantiodifferentiation process. In contrast, the entropy effect does not appear to play a significant role in the photocyclodimerization of AC with rigidly capped g-CDs. The differential enthalpy and entropy changes obtained for the enantiodifferentiating photocyclodimerization mediated by native and most of the modified g-CDs gave an excellent enthalpy-entropy compensation plot with an exception of the biphenyl-capped g-CD, indicating the operation of significantly different enantiodifferentiation mechanism within the rigidly capped cyclodextrin cavity. |
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