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[摘要]：Highly specific and precise mechanisms have evolved for transport of mRNAs to subcellular regions in polarized eukaryotic cells. RNA localization is largely thought to be driven by RNA structures that are recognized by RNA-binding proteins. In this issue of The EMBO Journal, Kilchert and Spang (2011) show that yeast ABP140 mRNA is localized through a translation-dependent mechanism. The first 17 amino acids of the nascent ABP140 peptide chain confer this activity. Much attention has been directed to mRNAs moving into the budding daughter cell of yeast. ABP140 mRNA goes the wrong way, localizing the mother cell's pole opposite to the bud. Moreover, the cotranslational localization motif in the ABP140 N terminus is able to overcome RNA structure-driven transport. This provides a novel mechanism to target mRNAs to subcellular sites that may be shared by other mRNAs that pave routes to previously unrecognized destinations. |
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