Permanent and Peripheral Embolization: Temperature-Sensitive p(N-Isopropylacrylamide-co-butyl Methylacrylate) Nanogel as a Novel Blood-Vessel-Embolic Material in the Interventional Therapy of Liver Tumors

[摘要]：Permanent and peripheral embolization is a requirement of embolic materials in the transcatheter arterial embolization of liver tumors. So far, it has been diffi cult to find materials that have both good flowability and high mechanical strength. In the present work, a temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) (PIB) nanogel is explored as a novel blood-vessel-embolic material in the interventional therapy of liver tumors. With increasing temperature, the PIB nanogel dispersion sequentially exhibits three phase states; swollen gel, flowable sol, and finally shrunken gel. Iohexol, a nonionic X-ray contrast agent, increases the volume-phase transition temperature of the PIB nanogel and decreases the critical gelation concentration. Angiographical and histological studies on the embolization in the liver arteries of VX2 tumor-bearing rabbits indicate that the PIB nanogel dispersion mixed with iohexol (designated as PIB-I-6150) completely occludes all levels of blood vessels, including peripheral vessels. In addition, data on tumor volume, necrosis level, and the number of metastatic foci indicate that PIB-I-6150 has better peripheral embolization than Lipiodol. Experiments concerning cytotoxicity, hemolysis, histology, and liver function indicate that PIB-I-6150 has good biocompability.

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