O-Selective Condensation Using P-N Bond Cleavage in RNA Synthesis without Base Protection.

[摘要]：In RNA synthesis without base protection, a new method for O-selective condensation with more than 99% selectivity was developed by 6-nitro-HOBt-mediated cleavage of undesired P(III)-N bonds on nucleobase moieties. Moreover, it is the first time for the synthesis of oligoRNAs without base protection to be successful.

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