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Cerinolactone, a Hydroxy-Lactone Derivative from Trichoderma cerinum

  作者 Vinale, F; Girona, IA; Nigro, M; Mazzei, P; Piccolo, A; Ruocco, M; Woo, S; Rosa, DR; Herrera, CL; Lorito, M  
  选自 期刊  Journal of natural products;  卷期  2012年75-1;  页码  103-106  
  关联知识点  
 

[摘要]A novel metabolite, 3-hydroxy-5-(6-isopropyl-3-methylene-3,4,4a,5,6,7,8,8a-octahydronaphthalen-2-yl)dihydrofuran-2-one, trivially named cerinolactone (1), has been isolated from culture filtrates of Trichoderma cerinum together with three known butenolides containing the 3,4-dialkylfuran-2(5H)-one nucleus, harzianolide (2), T39butenolide (3), and dehydroharzianolide (4). The structure of 1 was determined by spectroscopic methods, including UV, MS, and ID and 2D NMR analyses. In vitro tests with the purified compound exhibited activity against Pythium ultimum, Rhizoctonia solani, and Botrytis cinerea.

 
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