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[摘要]：The Rh(I)-catalyzed direct arylation of azines has been developed Quinolines and 2-substituted pyridines couple with aryl bromides to efficiently afford ortho-arylated azine products using the commercially available and air-stable catalyst [RhCl(CO)(2)](2) Electron-deficient and electron-rich aromatic bromides couple in good yields, and hydroxyl, chloro, fluoro, trifluoromethyl, ether, and ketone functionalities are compatible with the reaction conditions Aroyl chlorides also serve as effective azine coupling partners to give ortho-arylation products via a decarbonylation pathway |
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