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An efficient method for the selective iodination of a,b-unsaturated ketones.

  作者 Wang, Zihua;Yin, Guodong;Qin, Jing;Gao, Meng;Cao, Liping;Wu, Anxin;  
  选自 期刊  Synthesis;  卷期  2008年-22;  页码  3675-3681  
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[摘要]An efficient approach to a,b-unsatd. a'-iodo ketones directly from a,b-unsatd. ketones by selective iodination at the a'-position, without effect on the double bond and the activated benzene ring, in the presence of copper(II) oxide/iodine is described. The present method has the advantages of high yields, short reaction times, inexpensive reagents, mild reaction conditions, ease of manipulation, and the formation of cleaner products.

 
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