Efficient one-pot synthesis of 1,3-disubstituted pyridin-2(1H)-ones from a-hydroxyketene S,S-acetals under Vilsmeier conditions.

[摘要]：A facile and efficient one-pot synthesis of 1,3-disubstituted pyridin-2(1H)-ones, e.g., I, is developed via a novel cascade reaction of readily available a-hydroxy-a-carbamoyl ketene S,S-acetals under Vilsmeier conditions (DMF/POCl3) and a mechanism of this domino reaction is proposed.

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