| |
[摘要]：Trypanothione (TSH(2)), a metabolite unique to trypanosomal parasites, was evaluated as a potential biomarker for trypanosomal infection using fluorescence as the means of detection. Fluoroescein arsenical helix binder (FLASH) was prepared and used to detect TSH(2). Since it has low background fluorescence and forms a highly emissive complex with TSH(2), it can be used to detect low micromolar concentrations of TSH(2) in serum. The large dynamic range of FLASH and its selectivity for detection of the dithiol metabolite indicate that arsenical probes may offer a promising new platform for the diagnosis of trypanosomal infection. |
|
