Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead

[摘要]：Starting from a weak omeprazole screening hit, replacement of the pyridine with a 1,3-benzodioxole moiety, modi. cation of the thioether linkage, and substitution of the benzimidazole pharmacophore led to the discovery of nanomolar BRS-3 agonists. (c) 2008 Elsevier Ltd. All rights reserved.

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