[摘要]：A convergent synthesis of a series of 4,4'-functionalized 1,1'-biisoquinolines via 1-chloro-4-hydroxyisoquinoline and substituted biphenyl- and phenylpyrimidine ethers as building blocks is described. The latter were prepd. by Williamson etherification of the resp. 4-hydroxybiphenyl- and -phenylpyrimidine precursors with dibromo alkanes, allowing variation of the spacer lengths. 1-Chloro-4-hydroxyisoquinoline was obtained from N-phthalimidoglycine Et ester through a Gabriel-Colman reaction as a key step. Linkage of the building blocks by etherification in the presence of K2CO3 gave the isoquinolines, which were submitted to a NiCl2-mediated homocoupling to yield the ligand systems.
